Draft Road Map for Ebola Vaccine Development
A draft road map for the expedited development, testing, manufacture, delivery and financing of Ebola vaccines has been published by a global group of experts supported by the Wellcome Trust. The development and delivery of safe and effective vaccines would make a huge contribution to containing Ebola in Guinea, Liberia and Sierra Leone, as well as improving responses to future outbreaks and providing a model for vaccine development against other emerging infectious disease, the expert group has concluded.
The panel of 26 international experts, convened by the Wellcome Trust and the Centre for Infectious Disease Research and Policy (CIDRAP) at the University of Minnesota, explains how the substantial scientific, financial, social and logistical challenges to rapid Ebola vaccine development and deployment can be overcome through collaboration between governments, industry and philanthropic bodies.
It highlights the potential need for multiple Ebola vaccines with different characteristics, which might enable different vaccination strategies such as ring-vaccination to prevent an outbreak from spreading, and prophylactic vaccination of highrisk individuals such as healthcare workers. The recommendations are made in the interim report of Team B, which is co-chaired by Dr Jeremy Farrar, Director of the Wellcome Trust, and Professor Michael Osterholm, Director of CIDRAP.
The group is called “Team B” in recognition of the principal role played by the World Health Organisation and national governments in leading the international Ebola response.
Dr Jeremy Farrar, Director of the Wellcome Trust and co-chair of Team B, said: “As Guinea, Liberia and Sierra Leone make encouraging progress in containing Ebola, we must not lose sight of the immense contribution that a safe and effective vaccine would make towards controlling both this and future epidemics. We need urgent global collaboration between governments, industry and philanthropy to ensure candidate vaccines progress through trials to manufacture and delivery as swiftly as possible.
“The draft road map we publish today, agreed by a global group of experts, offers solutions to the great scientific, social, logistical and financial challenges of delivering an Ebola vaccine on this urgent timescale. It is a living document that will evolve as we learn more about Ebola and the candidate vaccines that are available. As well as being of great value in the present crisis, it will enable vaccine strategies to begin without delay in future outbreaks, and provide a model for vaccine development in response to other emerging infectious diseases.”
The Wellcome Trust is a global charitable foundation dedicated to improving health. The Wellcome Trust has provided approximately £10 million funding in response to the Ebola epidemic, which has enabled unparalleled international collaboration across the public, private and not-forprofit sectors to tackle the crisis. This includes trials of potential vaccines and treatments, in addition to public health, social and humanitarian research.